Hepatoprotective Activity of Solanum trilobatum Linn Against CCl4 Induced Hepatotoxicity in Rats
نویسندگان
چکیده
Hepatoprotective activity of the chloroform extract of the shade dried aerial parts of Solanum trilobatum Linn. was studied in wister rats using the CCl4 induced hepatotoxicity. The activity was evaluated by using biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP). The extract exhibited significant hepatoprotective activity at 300 mg/kg, p.o. body weight, which was comparable to the control and activity exhibited by the reference standard Silymarin in carbon tetrachloride induced hepatotoxicity model.
منابع مشابه
Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats.
BACKGROUND & OBJECTIVES Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Solanum trilobatum to treat hepatic diseases. Protective action of Solanum trilobatum extract (STE) was evaluated by us in an animal model of hepatotoxicity induced by carbon...
متن کاملHepatoprotective Activity of the Ethanolic Extract of Ficus carica Linn. Leaves in Carbon Tetrachloride- Induced Hepatotoxicity in Rats
The ethanolic extract of Ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic Albino rats induced via carbon tetrachloride. The degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), total protein (TP), total albumin (TA), alkaline phos...
متن کاملHepatoprotective Activity of the Ethanolic Extract of Ficus carica Linn. Leaves in Carbon Tetrachloride- Induced Hepatotoxicity in Rats
The ethanolic extract of Ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic Albino rats induced via carbon tetrachloride. The degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), total protein (TP), total albumin (TA), alkaline phos...
متن کاملHepatoprotective Activity of Portulaca quadrifida Linn against CCl4 Induced Hepatotoxicity in Rats
Hepatoprotective activity of the ethanolic extract of the shade dried aerial parts of Portulaca quadrifida Linn. was studied in wister rats using the CCl4 induced hepatotoxicity. The activity was evaluated by using biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidas...
متن کاملHepatoprotective Activity of Aerial Parts of Plumbago Zeylanica Linn against Carbon Tetrachloride-induced Hepatotoxicity in Rats
The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of aerial parts of Plumbago zeylanica in CCl4-induced hepatotoxicity in wistar rats. Silymarin (100mg/kg, p.o.) was given as reference drug. The extract of aerial parts of Plumbago zeylanica have shown very significant hepatoprotection against CCl4-induced hepatotoxicity in wistar rats by reducing se...
متن کامل